https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42668 Wed 31 Aug 2022 16:18:23 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50606 Wed 28 Feb 2024 15:56:56 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52738 Wed 25 Oct 2023 08:40:27 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48903 Wed 19 Apr 2023 16:32:54 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47164 Wed 14 Dec 2022 15:49:08 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16812 Wed 11 Apr 2018 12:55:19 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28036 Wed 11 Apr 2018 12:47:04 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20638 Wed 11 Apr 2018 09:20:21 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45382 Thu 27 Oct 2022 16:12:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30084 Thu 03 Feb 2022 12:18:07 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31622 Sat 24 Mar 2018 08:45:07 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22280 in silico and confirmed in luciferase reporter assays. miR-9 function was inhibited with sequence-specific antagomirs. The efficacy of DEX was assessed by quantifying glucocorticoid receptor (GR) cellular localization, protein phosphatase 2A (PP2A) activity, and AHR. Results: Exposure of pulmonary macrophages to IFN-γ/LPS synergistically induced miR-9 expression; reduced levels of its target transcript, protein phosphatase 2 regulatory subunit B (B56) δ isoform; attenuated PP2A activity; and inhibited DEX-induced GR nuclear translocation. Inhibition of miR-9 increased both PP2A activity and GR nuclear translocation in macrophages and restored steroid sensitivity in multiple models of steroid-resistant AHR. Pharmacologic activation of PP2A restored DEX efficacy and inhibited AHR. MiR-9 expression was increased in sputum of patients with neutrophilic but not those with eosinophilic asthma. Conclusion: MiR-9 regulates GR signaling and steroid-resistant AHR. Targeting miR-9 function might be a novel approach for the treatment of steroid-resistant asthma.]]> Sat 24 Mar 2018 07:17:42 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47479 Mon 23 Jan 2023 11:40:32 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53028 Mon 13 Nov 2023 08:49:08 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38495 Mon 09 May 2022 16:16:36 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40279 Mon 08 Aug 2022 11:55:28 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48645 Fri 24 Mar 2023 13:44:36 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52669 Fri 20 Oct 2023 09:24:41 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52668 Fri 20 Oct 2023 09:24:13 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42298 Fri 19 Aug 2022 15:05:25 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49786 Fri 02 Jun 2023 17:27:41 AEST ]]>